Therapeutic Interruption of T Cell Development Generates High-Affinity T Cells That Escape Exhaustion and Improve Cancer Immunotherapy
E. Dhuey, O. Oldridge, R. Ravishankar, H. Dada, Y. Yu, M. S. Anderson, A. J. Minn
This study shows that interrupting central tolerance generates high-affinity T cells that avoid exhaustion and enhance cancer immunotherapy.
bioRxiv · Jan 19, 2022 · PreprintImmunology