Optimized CART Cell Therapy for Metastatic Aggressive Thyroid Cancer
C. Manriquez-Roman, E. L. Siegler, J. J. Gleba, T. N. Huynh, G. E. DeFranco, A. Alasonyalilar Demirer, M. L. Pawlush, M. Redig, S. M. Klinge, L. K. Mai, J. L. Miller, E. E. Miller, B. L. Kimball, E. E. Tapper, R. L. Sakemura, , S. S. Kenderian
This paper develops a TSHR-targeted CART cell therapy for thyroid cancer and shows that combining it with MAPK inhibitors improves antitumor efficacy in dedifferentiated thyroid cancers.
bioRxiv · Mar 15, 2024 · PreprintImmunology