Telomerase RNA structural heterogeneity in living human cells detected by DMS-MaPseq
N. M. Forino, J. Z. Woo, A. J. Zaug, A. G. Jimenez, E. Edelson, T. R. Cech, S. Rouskin, M. Stone
This study identifies a misfolded CR4/5 conformation in hTR that is not required for hTERT binding and is detrimental to telomerase activity.
bioRxiv · Oct 4, 2023Biochemistry