M. Stone

Biological and Genetic Determinants of Glycolysis: Phosphofructokinase Isoforms Boost Energy Status of Stored Red Blood Cells and Transfusion Outcomes

The paper identifies genetic polymorphisms and metabolite levels in stored red blood cells that correlate with hemolysis and transfusion outcomes.

Ferroptosis regulates hemolysis in stored murine and human red blood cells

This study identifies Steap3 as a regulator of ferroptosis-like lipid peroxidation in stored RBCs, linking genetic variants to hemolysis in mice and human blood donors.

Unraveling the Phenotypic States of Human innate-like T Cells: Comparative Insights with Conventional T Cells and Mouse Models

This study compares human innate-like T cells (Tinn) with conventional T cells and mouse models, revealing distinct transcriptional programs and developmental pathways.

Telomerase RNA structural heterogeneity in living human cells detected by DMS-MaPseq

This study identifies a misfolded CR4/5 conformation in hTR that is not required for hTERT binding and is detrimental to telomerase activity.

Administration of vaccine-boosted COVID-19 convalescent plasma to SARS-CoV-2 infected hamsters decreases virus replication in lungs and hastens resolution of the infection despite transiently enhancing disease and lung pathology.

This study shows that vaccine-boosted convalescent plasma reduces SARS-CoV-2 replication in hamsters but temporarily worsens disease and lung pathology.

The small mycobacterial ribosomal protein, bS22, modulates aminoglycoside accessibility to its 16S rRNA helix-44 binding site

This study shows that the mycobacterial ribosomal protein bS22 modulates aminoglycoside binding to the 16S rRNA helix-44 site, influencing antibiotic resistance.

Early Seasonal Increases and Persistence in Relative Abundance of Potentially Toxic Cyanobacteria: Concerning Impacts of Extended Ice-Free Periods in Northern Temperate Lakes

This study shows that potentially toxic cyanobacteria persist in northern temperate lakes year-round, with increased abundance linked to extended ice-free periods and nutrient availability.

Polymorphic KIR3DL3 expression modulates tissue-resident and innate-like T cells.

This study identifies KIR3DL3 expression in T cells, showing it is upregulated by unconventional stimulation and varies by individual genetic variants.

HIV-specific CD8 T cells from elite controllers have an epigenetic imprint that preserves effector functions

This study identifies epigenetic and transcriptional features in HIV-specific CD8 T cells from elite controllers that support long-lived effector functions and developmental potential.

Early post-infection treatment of SARS-CoV-2 infected macaques with human convalescent plasma with high neutralizing activity reduces lung inflammation

This study treats SARS-CoV-2 infected macaques with high-titer convalescent plasma, showing reduced lung inflammation without affecting virus replication.

Distinct cellular immune signatures in acute Zika virus infection are associated withhigh or low persisting neutralizing antibody titers

The paper uses mass cytometry to identify immune cell signatures in acute ZIKV infection that predict high or low neutralizing antibody titers 6 months post-infection.

A Comprehensive Phylogenomic Platform for Exploring the Angiosperm Tree of Life

This paper introduces a phylogenomic platform for angiosperms, providing a large dataset and open tool for exploring the flowering plant tree of life.

Homology between the flagellar export apparatus and ATP synthetase: evidence from synteny predating the Last Universal Common Ancestor

The paper examines synteny between ATP synthetase and bacterial flagellar motor genes, finding deep conservation suggesting homology dating back to before LUCA.

Distinct SARS-CoV-2 Antibody Reactivity Patterns in Coronavirus Convalescent Plasma Revealed by a Coronavirus Antigen Microarray

This study uses a coronavirus antigen microarray to identify distinct antibody reactivity patterns in SARS-CoV-2 convalescent plasma, showing high concordance with existing assays and revealing clusters with potential implications for treatment efficacy.

Epitope-resolved profiling of the SARS-CoV-2 antibody response identifies cross-reactivity with an endemic human CoV

This study uses PepSeq to map SARS-CoV-2 antibody epitopes and identifies cross-reactivity with hCoV-OC43.

Analysis of SARS-CoV-2 Antibodies in COVID-19 Convalescent Blood using a Coronavirus Antigen Microarray

This paper validates a coronavirus antigen microarray to distinguish SARS-CoV-2 convalescent blood from pre-pandemic controls, showing improved discrimination with spike and nucleoprotein antigens.

Membrane metalloendopeptidase suppresses prostate carcinogenesis by attenuating effects of gastrin-releasing peptide on stem/progenitor cells

This study shows MME suppresses prostate cancer by inhibiting GRP/GRPR signaling in stem/progenitor cells, and identifies GRPR as a therapeutic target in MME-low cancers.

Assessing intra-lab precision and inter-lab repeatability of outgrowth assays of HIV-1 latent reservoir size

This study assesses the precision and repeatability of HIV-1 latent reservoir size measurements using QVOA across labs and storage conditions, finding assay variability and supporting frozen storage.