Aggregation-prone peptides modulate interferon gamma functionality in naturally occurring protein nanoparticles
J. V. Carratala, O. Cano-Garrido, J. M. Sanchez, C. Membrado, E. Perez, O. Conchillo-Sole, X. Daura, A. Sanchez-Chardi, A. Villaverde, A. Aris, E. Garcia-Fruitos, N. Ferrer-Miralles
This study shows that aggregation-prone peptides enhance the formation of protein nanoparticles from interferon-gamma in Lactococcus lactis, with compact protein conformations correlating with increased biological activity.
bioRxiv · Jan 3, 2019 · PreprintMicrobiology