A heterogeneous pool of tumor precursor cells with self-replenishing and tumor-originating properties in Chronic Lymphocytic Leukemia
B. Budeus, M. Dampmann, A. Kibler, B. Fassbender, M. Brauser, K. Bronischewski, E. Homp, S. Taudien, P. Johansson, J. Bloehdorn, S. Stilgenbauer, J. von Tresckow, J. Duerig, H. C. Reinhardt, R. Kueppers, , M. Seifert
The paper identifies a heterogeneous subpopulation of CLL-related B cells with self-replenishing and tumor-initiating properties that contribute to disease progression and clonal evolution.
bioRxiv · May 4, 2022 · PreprintCancer Biology