Delineating redox cooperativity in water-soluble and membrane multiheme cytochromes through protein design
B. J. Hardy, P. Dubiel, E. L. Bungay, M. Rudin, C. Williams, C. J. Arthur, M. J. Guberman-Pfeffer, A. S. F. Oliveira, P. Curnow, J. L. R. Anderson
This study uses de novo protein design to investigate redox cooperativity in multiheme cytochromes, showing that membrane burial enhances heme-heme electrostatic coupling.
bioRxiv · Mar 21, 2024Biochemistry