C. Williams

Gliomas phenocopy an inborn error of metabolism to drive neuronal activity and tumor growth

This study identifies GAA accumulation in gliomas as a driver of neuronal activity and tumor growth, linking cancer metabolism to neuroscience through GABAA receptor activation.

An interim exploratory biomarker analysis of a Phase 2 clinical trial to assess the impact of CT1812 in Alzheimers disease

This paper reports exploratory CSF proteomics data from a Phase 2 trial of CT1812 in Alzheimer's disease, identifying pharmacodynamic biomarkers and mechanistic insights.

Bivariate multilevel meta-analysis of log response ratio and standardized mean difference for robust and reproducible environmental and biological sciences

This paper introduces a bivariate multilevel meta-analysis method for log response ratio and standardized mean difference to improve reproducibility and reduce false positives in environmental and biological meta-analyses.

Delineating redox cooperativity in water-soluble and membrane multiheme cytochromes through protein design

This study uses de novo protein design to investigate redox cooperativity in multiheme cytochromes, showing that membrane burial enhances heme-heme electrostatic coupling.

Integrating environmental and ecological monitoring with seaweed farming

The paper assesses biodiversity impacts of seaweed and shellfish farms in Pembrokeshire using affordable monitoring methods, finding no negative impacts despite farming intensification.

3D Mitochondrial Structure in Aging Human Skeletal Muscle: Insights into MFN-2 Mediated Changes

This study investigates age-related changes in mitochondrial 3D structure in human skeletal muscle and shows that exercise can restore mitochondrial integrity through mitofusin 2.

The dynamics and longevity of circulating CD4+ memory T cells depend on cell age and not the chronological age of the host

This study shows that memory CD4+ T cell persistence depends on cell age, not host chronological age, using mouse models and mathematical models.

IL-1β inhibition partially negates the beneficial effects of diet-induced lipid lowering

This study shows that inhibiting IL-1β in mice reduces the beneficial effects of diet-induced lipid lowering on atherosclerosis, increasing plaque burden and decreasing plaque stability.

Keywords to success: a practical guide to maximise the visibility and impact of academic papers

The paper provides evidence-based recommendations to improve the discoverability and impact of academic papers through optimized use of keywords and abstract structure.

Quantitative Assessment of Morphological Changes in Lipid Droplets and Lipid-Mito Interactions with Aging in Brown Adipose

This study quantifies age-related changes in lipid droplet morphology and mitochondria-lipid interactions in murine brown adipose tissue using 3D imaging and analysis.

Colonization during a key developmental window reveals microbiota-dependent shifts in growth and immunity during undernutrition

This study uses a gnotobiotic mouse model to show that intergenerational microbiota colonization during early life affects growth and immunity under undernutrition conditions.

Eosinophils exert direct and indirect anti-tumorigenic effects in the development of esophageal squamous cell carcinoma

This study shows eosinophils reduce esophageal squamous cell carcinoma by releasing reactive oxygen species and inhibiting IL-17 pathways.

Ablation of Sam50 is associated with fragmentation and alterations in metabolism in murine and human myotubes

This study shows that Sam50 deficiency in myotubes leads to mitochondrial fragmentation, altered metabolism, and impaired oxidative capacity in both mice and humans.

PAK1-dependant mechanotransduction enables myofibroblast nuclear adaptation and chromatin organisation during fibrosis

The paper identifies PAK1-dependent mechanotransduction as critical for myofibroblast nuclear adaptation and chromatin organization during fibrosis, showing its impact on gene regulation and disease progression.

Pulmonary osteoclast-like cells in silica induced pulmonary fibrosis

The paper investigates silica-induced pulmonary fibrosis in mice, finding that silica triggers osteoclast-like differentiation of macrophages and monocytes, contributing to lung injury and fibrosis.

ALiCE: A versatile, high yielding and scalable eukaryotic cell-free protein synthesis (CFPS) system

This paper introduces ALiCE, a scalable eukaryotic cell-free protein synthesis system capable of producing complex proteins at high yields and demonstrating functional activity and post-translational modifications.

Within-host diversity improves phylogenetic and transmission reconstruction of SARS-CoV-2 outbreaks

This study shows that incorporating within-host genetic diversity improves phylogenetic and transmission reconstruction of SARS-CoV-2 outbreaks.

Genomic surveillance of carbapenem-resistant Klebsiella in Wales reveals persistent spread of K. pneumoniae ST307 and adaptive evolution of pOXA-48-like plasmids

This study analyzes Klebsiella isolates from Wales to track the spread of resistant strains and plasmids, identifying ST307 and pOXA-48-like plasmids as key drivers of carbapenem resistance.

CTLA-4 regulates PD-L1-PD-1 interactions via transendocytosis of CD80

The paper investigates how CTLA-4 regulates PD-L1-PD-1 interactions through CD80 transendocytosis, showing that CD80 removal enables PD-L1 recovery and that CTLA-4's cytoplasmic domain is essential for this process.

US Dog Importations during the COVID-19 Pandemic: Do we have an erupting problem?

The paper analyzes US dog importation data during the COVID-19 pandemic and finds a 52% increase in denied entries in 2020, primarily due to falsified rabies certificates, with three countries accounting for 74% of denials.

Molecular adaptation to folivory and the conservation implications for Madagascar's lemurs

This study examines genetic adaptation in RNASE1 across folivorous lemurs to understand dietary specialization and its conservation implications.

Dynamics of repair and regeneration of adult zebrafish respiratory gill tissue after cryoinjury.

This study investigates zebrafish gill regeneration after cryoinjury, identifying FIBIN as a gene involved in resolving tissue damage without fibrosis.

Rigidifying a de novo enzyme increases activity and induces a negative activation heat capacity

This study shows that increasing rigidity in a de novo peroxidase enhances its activity but alters its temperature dependence, resembling natural enzymes.

Recurrent Vulvovaginal Candidiasis; a dynamic interkingdom biofilm disease of Candida and Lactobacillus

This study investigates RVVC by analyzing the vaginal microbiome and interactions between Candida and Lactobacillus, finding reduced L. crispatus and increased L. iners, and showing Lactobacillus inhibition of Candida biofilm formation.

Molecular mechanism for kinesin-1 direct membrane recognition

This paper identifies a conserved amphipathic helix in kinesin-1 light chains that mediates direct membrane binding, challenging the previous understanding of lysosome positioning.

Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH)

This study compares the efficacy of three THRβ agonists in modulating gene expression related to cholesterol and fatty acid metabolism in human and rat models.

Inhibition of Streptococcus pneumoniae autolysins highlight distinct differences between chemical and genetic inactivation

The paper identifies a diamide inhibitor of Streptococcus pneumoniae growth and shows that genetic and chemical inactivation of autolysins yield different phenotypic outcomes.

Extracellular matrix and cyclic stretch alter fetal cardiomyocyte proliferation and maturation in a rodent model of heart hypoplasia

This study investigates how extracellular matrix and cyclic stretch affect cardiomyocyte proliferation and maturation in a rodent model of heart hypoplasia, finding that hypoplastic cardiomyocytes remain immature and show altered responses to mechanical cues.

Tsetse salivary glycoproteins are modified with paucimannosidic N-glycans, are recognised by C-type lectins and bind to trypanosomes

The paper characterizes the N-glycan profile of tsetse salivary glycoproteins and shows they bind trypanosomes and are recognized by C-type lectins.

Candida auris phenotypic heterogeneity determines pathogenicity in vitro

This study compares non-aggregative and aggregative Candida auris isolates to determine how their phenotypic differences affect biofilm formation and immune response in a 3D skin model.