Human caspase-1 autoproteolysis is required for ASC-dependent and -independent inflammasome activation
D. P. Ball, C. Y. Taabazuing, A. R. Griswold, E. L. Orth, S. D. Rao, I. B. Kotliar, D. C. Johnson, D. A. Bachovchin
This study shows that pro-caspase-1 autoproteolysis is required for both ASC-dependent and -independent inflammasome activation in human cells.
bioRxiv · Jun 24, 2019 · PreprintImmunology