Author

E. Macintyre

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Approach:statistical model· 2 Assay:whole-exome sequencing· 2

Frequent Co-Authors

V. Asnafi· 4 shared E. Verhoeyen· 2 shared G. Hypolite· 2 shared L. Lhermitte· 2 shared P. Villarese· 2 shared A. Attarbaschi· 1 shared A. Beishuizen· 1 shared A. Cumano· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersCancer Biology

V. Asnafi

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Mutational and transcriptional landscape of pediatric B-cell precursor lymphoblastic lymphoma

E. Kroeze, I. Iaccarino, M. M. Kleisman, M. Mondal, T. Beder, M. Khouja, M. P. Hoeppner, M. Scheijde-Vermeulen, L. A. Kester, M. Brueggemann, C. D. Baldus, G. Cario, R. S. Bladergroen, N. Garnier, A. Attarbaschi, , W. Klapper

This study presents the first comprehensive mutational and transcriptional analysis of B-cell precursor lymphoblastic lymphoma (BCP-LBL), revealing molecular similarities to BCP-ALL but with distinct mutation patterns in epigenetic modifiers.

bioRxiv · Dec 27, 2023Cancer Biology

ATP citrate lyase is an essential player of the metabolic rewiring induced by PTEN loss during T-ALL development.

G. Andrieu, G. Hypolite, E. Balducci, C. Costa, E. Verhoeyen, I. Nemazanyy, G. Panasyuk, K. Wellen, E. Macintyre, V. Asnafi, M. Tesio

This study identifies ATP citrate lyase (ACLY) as a critical metabolic driver in PTEN-deficient T-ALL, showing its essential role in disease progression and therapeutic targeting potential.

bioRxiv · Mar 27, 2023Cancer Biology

Multimodal Mapping of Human Lymphopoiesis Reveals B and T/NK/ILC Lineages are Subjected to Cell-Intrinsic versus Flt3L-Dependent Regulation

K. Alhaj Hussen, E. Chabaane, E. Nelson, S. Lekiashvili, S. Diop, S. Keita, b. Evrard, A. Lardenois, M. Delord, E. Verhoeyen, K. Cornils, Z. Kasraian, E. Macintyre, A. Cumano, D. garrick, , B. Canque

This study maps human lymphopoiesis using multimodal approaches, showing B and T/NK/ILC lineages are regulated differently: cell-intrinsically versus Flt3L-dependent.

bioRxiv · Dec 12, 2022 · PreprintImmunology

Oncogenetic Landscape Of Lymphomagenesis In Coeliac Disease

S. Cording, L. Lhermitte, G. Malamut, S. Berrabah, A. Trinquand, N. Guegan, P. Villarese, S. Kaltenbach, B. Meresse, S. Khater, M. Dussiot, M. Bras, M. Cheminant, B. Tesson, C. Bole-Feysot, , N. Cerf-Bensussan

This study identifies JAK1-STAT3 pathway mutations as key drivers of lymphomagenesis in celiac disease-associated RCDII and EATL.

bioRxiv · Sep 7, 2020Cancer Biology

A transcriptomic continuum of differentiation arrest identifies myeloid interface acute leukemias with poor prognosis

J. Bond, A. Krzywon, L. Lhermitte, C. Roumier, A. Roggy, M. Belhocine, A. K. Kheirallah, P. Villarese, G. Hypolite, F. Garnache-Ottou, S. Castaigne, N. Boissel, V. Asnafi, C. Preudhomme, H. Dombret, , E. Macintyre

The paper identifies a transcriptomic continuum of differentiation arrest in acute leukemias, finding that myeloid/T-lymphoid interface leukemias (IALs) correlate with poor prognosis in AML.

bioRxiv · Dec 10, 2019Cancer Biology