Lipid membrane templated misfolding and self-assembly of intrinsically disordered tau protein
E. Y. Chi, J. Majewski, E. Jones, C. Vander Zanden, J. Biernat, E. Mandelkow
This study investigates how lipid membranes influence tau protein misfolding and aggregation, showing that membrane binding induces phase separation and beta-sheet oligomer formation.
bioRxiv · Mar 4, 2020Biophysics