Multivalent, Bispecific ????B7-H3-????CD3 Chemically Self-Assembled Nanorings Direct Potent T-cell Responses Against Medulloblastoma
E. Mews, P. J. Beckmann, M. Patchava, Y. Wang, D. A. Largaespada, C. R. Wagner
This paper designs and tests bispecific nanorings targeting B7-H3 and CD3 to enhance T-cell responses against medulloblastoma, showing improved tumor infiltration and reduced toxicity.
bioRxiv · Mar 15, 2022Cancer Biology