Y. Wang

The Genome In A Bottle HG002 assembly-based variant benchmark set enables comprehensive benchmarking of small and structural variants.

The paper introduces a comprehensive variant benchmark set derived from a high-quality diploid assembly, improving small and structural variant detection across complex genomic regions.

J chain dictates the recognition of IgA by FcRL4

The paper determines that FcRL4 recognizes IgA via the J chain, revealing structural and functional differences in IgA receptor interactions.

Dorsal prefrontal cortex drives perseverative behavior in mice

This study identifies the dorsal prefrontal cortex, specifically anterior supplementary motor cortex, as a driver of perseverative behavior in mice during a reward learning task.

Scalable Generation of Clinical-Grade Universal Human cDC1s Enables Potent Antitumor Immunotherapy

This paper develops a scalable method to generate clinical-grade cDC1s from umbilical cord blood, showing improved antitumor efficacy in mouse models and recapitulating DC differentiation.

Generative Neural Spike Prediction from Upstream Neural Activity via Behavioral Reinforcement

This paper develops a reinforcement learning framework to predict downstream neural spike trains from upstream activity using behavioral rewards, achieving better behavioral performance than existing methods.

Dynamic Regulation of Innate Lymphoid Cell Development During Ontogeny

This study investigates the developmental changes in innate lymphoid cell (ILC) subsets using scRNA-seq and differentiation assays, revealing distinct regulatory programs in fetal and adult stages.

Coronary Microvascular Dysfunction is Associated with Augmented Lysosomal Signaling in Hypercholesterolemic Mice

This study shows that hypercholesterolemia causes coronary microvascular dysfunction in mice through enhanced lysosomal signaling in endothelial cells, which can be mitigated by ezetimibe.

Omicron-specific ultra-potent SARS-CoV-2 neutralizing antibodies targeting the N1/N2 loop of Spike N-terminal domain

This study identifies ultra-potent Omicron-specific antibodies targeting the N1/N2 loop of the Spike NTD, which neutralize SARS-CoV-2 by competing with ACE2 and blocking S1 shedding, but are evaded by BA.2.86 and BA.2.87.1 sublineages.

BMP9 and BMP10 coordinate liver cellular crosstalk to maintain liver health

This study shows that HSCs produce BMP9/10, which regulate KCs and ECs to maintain liver homeostasis, and their deletion leads to fibrosis and iron overload.

Unraveling the Role of Ctla-4 in Intestinal Immune Homeostasis: Insights from a novel Zebrafish Model of Inflammatory Bowel Disease

This study identifies a zebrafish model of IBD by knocking out Ctla-4, showing similar intestinal inflammation and immune dysregulation to mammalian IBD.

SLC45A4 encodes a peroxisomal putrescine transporter that promotes GABA de novo synthesis

The paper identifies SLC45A4 as a peroxisomal putrescine transporter that enhances GABA de novo synthesis via the AOP pathway.

PA28γ promotes the malignant progression of tumor by elevating mitochondrial function via C1QBP

This study identifies PA28γ's role in promoting oral squamous cell carcinoma progression by enhancing mitochondrial function through interaction with C1QBP.

Size evolution of gigantic genomes suggests stochastic outcomes of transposable element/host silencing interactions

The paper examines TE/host interactions in salamander genomes and finds no correlation between genome size and TE deletion rates or suppression, suggesting stochastic TE accumulation in gigantic genomes.

Shrimp Hemocyanin elicits a potent humoral response in mammals and is favorable to hapten conjugation

This study shows shrimp hemocyanin (SHC) can replace keyhole limpet hemocyanin (KLH) as a carrier protein for hapten conjugation, offering better solubility and comparable immunogenicity in mammals.

Linalool fumigation improves mating competitiveness of males for population suppression of the global fruit pest Cydia pomonella

This study finds that linalool fumigation improves mating competitiveness of X-ray-sterilized Cydia pomonella males, enhancing the effectiveness of sterile insect technique for population suppression.

A Metagenomic Approach Does Not Elucidate Uremic Toxin Levels in Hemodialysis Patients.

This study investigates the relationship between fecal microbiome and serum uremic toxins in hemodialysis patients, finding that dietary protein-to-fiber ratio, not microbiome composition, is significantly associated with toxin levels.

TPM4 condensates glycolytic enzymes to fuel actin reorganization under hyperosmotic stress

The paper shows that TPM4 forms condensates with glycolytic enzymes under hyperosmotic stress, linking actin reorganization to metabolic activity.

BRAT1 - a new therapeutic target for glioblastoma

This study identifies BRAT1 as a key driver of glioblastoma growth and invasion, showing that its inhibition with CurD reduces tumor migration and enhances radiation sensitivity.

Multi-omic profiling of intraductal papillary neoplasms of the pancreas reveals distinct expression patterns and potential markers of progression

This study profiles proteins and glycoproteins in pancreatic neoplasms to identify expression patterns and potential progression markers.

Fluorogenic Aptamer Optimizations on a Massively Parallel Sequencing Platform

This paper optimizes a DNA-based fluorogenic aptamer (D-FAP) using a screening-and-simulation pipeline on a repurposed sequencing platform, achieving improved fluorescence properties.

INF2-mediated actin polymerization at ER-organelle contacts regulates organelle size and movement

This study shows INF2-mediated actin polymerization at ER-organelle contacts regulates organelle size and movement through high-resolution imaging and genetic manipulation.

Cell sorting based on single nucleotide variation enables characterization of mutation-dependent transcriptome and chromatin states.

The paper develops STAR-FACS to sort cells by SNVs and shows distinct transcriptomes in glioblastoma cells with different TERT promoter mutations.

Deterministic processes played more important roles than stochastic processes in driving community assembly of ectomycorrhizal fungal associated with Pinus tabuliformis - an endemic Pinaceae species in China

The study examines EM fungal communities associated with Pinus tabuliformis, finding deterministic processes dominate community assembly over stochastic processes.

Synergically enhanced anti-tumor immunity of in vivo CAR by circRNA vaccine boosting

This study develops circRNA-based in vivo CAR and vaccines that synergistically enhance anti-tumor immunity in mice.

Integrated Analysis of Single-Cell and Bulk RNA-Seq Data reveals that Ferroptosis-Related Genes Mediated the Tumor Microenvironment predicts Prognosis, and guides Drug Selection in Triple-Negative Breast Cancer

This study integrates single-cell and bulk RNA-seq data to identify ferroptosis-related genes in TNBC, developing a risk score model to predict prognosis and guide drug selection.

Agent-Based Modeling of Virtual Tumors Reveals the Critical Influence of Microenvironmental Complexity on Immunotherapy Efficacy

This study compares ODE and ABM models to show how spatial components affect immunotherapy outcomes in tumors with different antigenicity and CTL killing mechanisms.

The Mammalian KU70 C-terminus SAP Domain Is Required to Repair Exogenous DNA Damage

This study shows that the KU70 SAP domain is essential for repairing exogenous DNA damage but not for V(D)J recombination or development.

Axial asymmetry organizes division plane orthogonality in Neisseria gonorrhoeae

This study shows that axial asymmetry in Neisseria gonorrhoeae guides orthogonal division planes, maintaining diplococcal morphology through ParB segregation and MinCDE system function.

The TissueTractor, a device for applying large strains to tissues and cells for simultaneous high-resolution live cell microscopy.

Single cell transcriptome profiling reveals pathogenesis of Bullous Pemphigoid

This study uses single-cell transcriptomics to identify functional changes in skin and blood cells during Bullous Pemphigoid, revealing key pathways and cell interactions involved in disease progression.