In vitro and in vivo efficacy of the combination of colistin and endolysins against clinical strains of Multi-Drug Resistant (MDR) pathogens
L. Blasco, A. Ambroa, R. Trastoy, E. Perez-Nadales, F. Fernandez-Cuenca, J. Torre-Cisneros, J. Oteo-Iglesias, A. Oliver, R. Canton, T. J. Kidd, F. Navarro, E. Miro, A. Pascual, G. Bou, L. Martinez-Martinez, M. Tomas
This study evaluates the in vitro and in vivo efficacy of combining colistin with endolysins ElyA1 and ElyA2 against MDR pathogens, finding that ElyA1 enhances colistin's antimicrobial activity and reduces its MIC.
Scientific Reports · Apr 28, 2020Peer-reviewedMicrobiology