R. Canton

Plasmid-encoded insertion sequences promote rapid adaptation in clinical enterobacteria

This study shows plasmid-encoded insertion sequences (IS1) enhance bacterial adaptation by increasing gene inactivation rates in clinical enterobacteria.

β-lactamase expression induces collateral sensitivity in Escherichia coli

This study shows that β-lactamase expression in E. coli induces collateral sensitivity to colistin and azithromycin, suggesting a therapeutic strategy to counter mobile AMR.

Long-term dynamics of the 'Serratia marcescens complex' in the hospital-built environment

The paper investigates the long-term dynamics of Serratia marcescens complex in hospital sinks, identifying persistent strains linked to outbreaks and revealing new insights into their ecology and resistance gene acquisition.

International and regional spread of carbapenem-resistant Klebsiella pneumoniae in Europe

This study analyzes genomic data of carbapenem-resistant K. pneumoniae strains from Europe to identify clonal complexes and carbapenemase genes, revealing regional differences in their spread.

Antimicrobial resistance level and conjugation permissiveness shape plasmid distribution in clinical enterobacteria

The paper investigates how antimicrobial resistance levels and conjugation permissiveness influence plasmid distribution in clinical enterobacteria, showing that specific bacterial clones stabilize plasmid spread.

The Impact of Colistin Resistance on the Activation of Innate Immunity by Lipopolysaccharide Modification

This study evaluates how colistin resistance in bacteria affects innate immune responses, finding that LPS modifications like Ara4N enhance bacterial survival and trigger stronger inflammation.

Application of RT-LAMP-CRISPR-Cas13a technology to the detection of OXA-48 producing Klebsiella pneumoniae

The paper develops an RT-LAMP-CRISPR-Cas13a assay for detecting OXA-48-producing Klebsiella pneumoniae in clinical samples with 100% specificity and sensitivity.

Within-patient evolution of plasmid-mediated antimicrobial resistance

This study tracks the evolution of plasmid-mediated antimicrobial resistance in hospitalized patients, revealing trade-offs between resistance levels and bacterial fitness.

A 21-year survey of Escherichia coli from bloodstream infections (BSIs) in a tertiary hospital reveals how community-hospital dynamics of the B2 phylogroup clones influence local BSI rates

This study analyzes 21 years of E. coli bloodstream infections in a hospital, showing how community and hospital dynamics of B2 phylogroup clones influence BSI rates.

Automatic discrimination of species within the Enterobacter cloacae complex using MALDI-TOF Mass Spectrometry and supervised algorithms

This paper develops machine learning models using MALDI-TOF MS data to accurately differentiate species within the Enterobacter cloacae complex.

Automatic antibiotic resistance prediction in Klebsiella pneumoniae based on MALDI-TOF mass spectra

This paper introduces a Bayesian model to predict antibiotic resistance in Klebsiella pneumoniae using MALDI-TOF mass spectra, outperforming existing methods by avoiding preprocessing and hyperparameter tuning.

Predation Efficiency upon Clinical Isolates: Bdellovibrio bacteriovorus is Prey Specific and Origin Dependent

This study evaluates the predation efficiency of Bdellovibrio bacteriovorus on clinical isolates of Serratia marcescens and Pseudomonas aeruginosa, finding that origin, not genetic background or antibiotic resistance, determines prey susceptibility.

Cannabidiol (CBD) repurposing as antibacterial: promising therapy of CBD plus polymyxin B against superbugs

This study evaluates CBD's antibacterial activity and its combination with polymyxin B against multidrug-resistant bacteria, showing synergistic effects against resistant strains.

Evolution of VIM-1 producing Klebsiella pneumoniae isolates from a hospital outbreak reveals the genetic bases of the loss of the urease-positive identification character

The paper analyzes the evolution of a multidrug-resistant K. pneumoniae outbreak, identifying genetic changes leading to antibiotic resistance and urease loss.

Global genomic population structure of Clostridioides difficile

This study introduces EnteroBase, a database for C. difficile genomic data, showing it can identify related genomes with 89% consistency between cgMLST and SNPs.

The distribution of plasmid fitness effects explains plasmid persistence in bacterial communities

The study determines the distribution of fitness effects for plasmid pOXA-48 in gut bacteria, showing quasi-neutral effects and beneficial effects in some isolates, and links plasmid persistence to bacterial diversity and phylogeny.

Collateral Sensitivity Associated with Antibiotic Resistance Plasmids

This study investigates collateral sensitivity associated with antibiotic resistance plasmids, showing its conservation in clinical isolates and potential for selective elimination of plasmid-carrying bacteria.

In vitro and in vivo efficacy of the combination of colistin and endolysins against clinical strains of Multi-Drug Resistant (MDR) pathogens

This study evaluates the in vitro and in vivo efficacy of combining colistin with endolysins ElyA1 and ElyA2 against MDR pathogens, finding that ElyA1 enhances colistin's antimicrobial activity and reduces its MIC.

Dissemination routes of the carbapenem resistance plasmid pOXA-48 in a hospital setting

This study characterizes the dissemination routes of the carbapenem resistance plasmid pOXA-48 in a hospital setting using mechanistic models and genomic data.

Reconstruction of Escherichia coli ancient diversification by layered phylogenomics and polymorphism fingerprinting

This paper uses layered phylogenomics and polymorphism fingerprinting to reconstruct the evolutionary history of Escherichia coli, identifying three root lineages and a new phylogroup, while highlighting adaptive strategies in different lineages.

Simulating multi-level dynamics of antimicrobial resistance in a membrane computing model

The paper uses a membrane computing model to simulate and analyze the multi-level dynamics of antimicrobial resistance across genes, clones, species, hosts, and environments.