Granzyme A inhibition reduces inflammation and increases survival during abdominal sepsis.
M. Arias, J. Pardo, M. Garzon, J. L. Sierra, L. Comas, L. Santiago, T. Khaliulina, I. Uranga, A. Ramirez, E. Tapia, E. Morte, S. Algarate, L. Couty, E. Camerer, P. I. Bird, , E. Galvez
This study shows that inhibiting Granzyme A reduces inflammation and improves survival in abdominal sepsis by decreasing proinflammatory markers without affecting bacterial load.
bioRxiv · Jun 5, 2020Immunology