Streptococcal Lancefield polysaccharides are critical cell wall determinants for human group IIA secreted phospholipase A2 to exert its bactericidal effects
V. P. van Hensbergen, E. Movert, V. de Maat, C. Luechtenborg, Y. Le Breton, G. Lambeau, C. Payre, A. Henningham, V. Nizet, J. A. G. Van Strijp, B. Bruegger, F. Carlsson, K. S. McIver, N. M. van Sorge
This study identifies Lancefield polysaccharides as critical for hGIIA to kill Group A and B Streptococcus by enabling penetration through the bacterial cell wall.
bioRxiv · Aug 16, 2018Microbiology