Author

G. Lambeau

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 7 Research Focus:host-pathogen & immune response· 6 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:metabolomics· 1 Assay:structural biology· 1

Frequent Co-Authors

C. Payre· 4 shared N. M. van Sorge· 4 shared V. P. van Hensbergen· 3 shared A. Ruda· 2 shared G. Widmalm· 2 shared J. A. G. van Strijp· 2 shared J. S. Rush· 2 shared K. S. McIver· 2 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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4 shared papersMicrobiology

C. Payre

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

The Free Fatty Acid-Binding Pocket is a Conserved Hallmark in Pathogenic β-Coronavirus Spike Proteins from SARS-CoV to Omicron

C. Toelzer, K. Gupta, S. K. N. Yadav, L. Hodgson, M. Kavanagh Williamson, D. Buzas, U. Borucu, K. Powers, R. Stenner, K. Vasileiou, F. Garzoni, D. Fitzgerald, C. Payre, G. Lambeau, A. D. Davidson, , C. Schaffitzel

The paper identifies a conserved free fatty acid-binding pocket in pathogenic β-coronavirus spike proteins that suppresses viral infection and replication.

bioRxiv · Apr 22, 2022Biochemistry

Interference with lipoprotein maturation sensitizes methicillin-resistant Staphylococcus aureus to human group IIA secreted phospholipase A2 and daptomycin.

M. M. Kuijk, Y. Wu, V. P. van Hensbergen, G. Shanlitourk, C. Payre, G. Lambeau, J. Herrmann, R. Müller, J. A. G. van Strijp, Y. Pannekoek, L. Touqui, N. M. van Sorge

This study identifies LspA as a key factor in hGIIA resistance in MRSA and shows that inhibiting LspA increases susceptibility to hGIIA and daptomycin.

bioRxiv · Feb 6, 2022 · PreprintMicrobiology

Lipid droplets control mitogenic lipid mediator production in human cancer cells

E. Jarc Jovicic, A. Pucer Janez, T. O. Eichmann, S. Koren, V. Brglez, P. M. Jordan, J. Gerstmeier, D. Lainscek, A. Golob-Urbanc, R. Jerala, G. Lambeau, O. Werz, R. Zimmermann, T. Petan

The paper shows lipid droplets regulate mitogenic lipid mediator production in cancer cells by controlling PUFAs availability through ATGL and DGAT1.

bioRxiv · Nov 25, 2021Biochemistry

PplD is a de-N-acetylase of the cell wall linkage unit of streptococcal rhamnopolysaccharides

J. S. Rush, P. Parajuli, A. Ruda, J. Li, A. A. Pohane, S. Zamakhaeva, M. M. Rahman, J. C. Chang, A. Gogos, C. W. Kenner, G. Lambeau, M. J. Federle, K. V. Korotkov, G. Widmalm, N. Korotkova

This study identifies PplD as a de-N-acetylase that modifies the cell wall linkage unit of streptococcal rhamnopolysaccharides, enhancing resistance to host antimicrobial proteins.

bioRxiv · Sep 23, 2021Microbiology

Discovery of glycerol phosphate modification on streptococcal rhamnose polysaccharides

R. J. Edgar, V. P. van Hensbergen, A. Ruda, A. G. Turner, P. Deng, Y. Le Breton, N. M. El-Sayed, A. T. Belew, K. S. McIver, A. G. McEwan, A. J. Morris, G. Lambeau, M. J. Walker, J. S. Rush, K. V. Korotkov, , N. Korotkova

The paper identifies a glycerol phosphate modification on streptococcal rhamnose polysaccharides, revealing its role in host-pathogen interactions and vaccine design.

bioRxiv · Jan 27, 2019Microbiology

Streptococcal Lancefield polysaccharides are critical cell wall determinants for human group IIA secreted phospholipase A2 to exert its bactericidal effects

V. P. van Hensbergen, E. Movert, V. de Maat, C. Luechtenborg, Y. Le Breton, G. Lambeau, C. Payre, A. Henningham, V. Nizet, J. A. G. Van Strijp, B. Bruegger, F. Carlsson, K. S. McIver, N. M. van Sorge

This study identifies Lancefield polysaccharides as critical for hGIIA to kill Group A and B Streptococcus by enabling penetration through the bacterial cell wall.

bioRxiv · Aug 16, 2018Microbiology

Group IIA secreted phospholipase A2 in human serum kills commensal but not clinical Enterococcus faecium isolates

F. L. Paganelli, H. L. Leavis, S. He, N. M. van Sorge, C. Payre, G. Lambeau, R. J. Willems, S. H. Rooijakkers

The paper shows human serum kills commensal Enterococcus faecium but not clinical isolates, mediated by hGIIA, highlighting a potential mechanism for hGIIA resistance in clinical strains.

bioRxiv · Feb 28, 2018Microbiology