Plasticity of extrachromosomal and intrachromosomal BRAF amplifications in mediating targeted therapy dosage challenges
K. Song, J. K. Minami, W. P. Crosson, J. Salazar, E. Pazol, N. T. Senaratne, N. Rao, K. Paraiso, T. G. Graeber
This study investigates how BRAF amplifications in different genomic forms enable melanoma cells to adapt to targeted therapy dose changes, revealing mechanisms of drug resistance.
bioRxiv · Nov 23, 2021Cancer Biology