Telomerase reverse transcriptase induces targetable alterations in glutathione and nucleotide biosynthesis in glioblastomas
S. Udutha, C. Taglang, G. Batsios…·P. Viswanath
This study identifies metabolic vulnerabilities in glioblastomas driven by TERT and shows that combining GCLC and glutamine-utilizing enzyme inhibitors synergistically targets these vulnerabilities.