The transcription factor RUNX2 drives the generation of human NK cells and promotes tissue residency
S. Wahlen, F. Matthijssens, W. Van Loocke, S. Taveirne, L. Kiekens, E. Persyn, E. van Ammel, Z. De Vos, S. De Munter, P. Matthys, F. Van Nieuwerburgh, T. Taghon, B. Vandekerckhove, P. Van Vlierberghe, G. Leclercq
This study shows that RUNX2 promotes human NK cell generation and tissue residency through IL-2Rβ induction, with implications for cancer therapy.
bioRxiv · May 2, 2022Immunology