The Ebola virus matrix protein clusters phosphatidylserine, a critical step in viral budding
M. L. Husby, S. Amiar, L. I. Prugar, E. A. David, C. B. Plescia, K. E. Huie, J. M. Brannan, J. M. Dye, E. Pienaar, R. V. Stahelin
This study shows that the Ebola virus matrix protein eVP40 clusters phosphatidylserine to promote viral budding, and that fendiline reduces this clustering, inhibiting virus production and entry.
bioRxiv · Jun 8, 2021 · PreprintMicrobiology