S. Amiar

Integrity of membrane fluidity and fatty acid environment are necessary for Ebola virus VP40 assembly and release of viral particles

This study shows that membrane fluidity and fatty acid composition are critical for Ebola virus VP40 assembly and viral particle release.

The Ebola virus matrix protein clusters phosphatidylserine, a critical step in viral budding

This study shows that the Ebola virus matrix protein eVP40 clusters phosphatidylserine to promote viral budding, and that fendiline reduces this clustering, inhibiting virus production and entry.

Lipid-specific protein oligomerization is regulated by two interfaces in Marburg virus matrix protein VP40

This study identifies two distinct oligomerization interfaces in Marburg virus VP40 that regulate lipid-specific protein oligomerization and matrix assembly at the plasma membrane.

SARS-CoV-2 viral budding and entry can be modeled using virus-like particles

This study develops a BSL-2-compatible system using SARS-CoV-2 virus-like particles to model viral budding and entry mechanisms and assess drug inhibitors.

Division and adaptation to host nutritional environment of apicomplexan parasites depend on apicoplast lipid metabolic plasticity and host organelles remodelling

This study shows that apicomplexan parasites adapt to host nutritional changes by shifting lipid acquisition between de novo synthesis and host scavenging, involving apicoplast lipid metabolism and host organelle remodeling.