RNF40-dependent epigenetic regulation of actin cytoskeletal dynamics is required for HER2-driven mammary tumorigenesis
F. Wegwitz, E. Prokakis, A. Pejkovska, R. L. Kosinsky, M. Glatzel, K. Pantel, H. Wikman, S. A. Johnsen
This study identifies RNF40's role in HER2-positive breast cancer by showing its requirement for H2B monoubiquitination, which regulates actin dynamics and tumor growth.
bioRxiv · Feb 24, 2020Cancer Biology