Frequent Aneuploidy in Primary Human T Cells Following CRISPR-Cas9 cleavage
A. D. Nahmad, E. Reuveni, E. Goldschmidt, T. Tenne, M. Liberman, M. Horovitz-Fried, R. Khosravi, H. Kobo, E. Reinstein, A. Madi, U. Ben-David, A. Barzel
This study finds frequent aneuploidy and chromosomal truncations in CRISPR-Cas9-edited primary human T cells, associated with reduced proliferation and p53 activation.
bioRxiv · Aug 20, 2021Bioengineering