BioengineeringbioRxiv
Frequent Aneuploidy in Primary Human T Cells Following CRISPR-Cas9 cleavage
A. D. Nahmad, E. Reuveni, E. Goldschmidt…·A. Barzel
This study finds frequent aneuploidy and chromosomal truncations in CRISPR-Cas9-edited primary human T cells, associated with reduced proliferation and p53 activation.