Structural basis for carbapenam C-alkylation by TokK, a B12-dependent radical SAM enzyme
H. Knox, E. Sinner, C. Townsend, A. Boal, S. Booker
The paper presents x-ray crystal structures of TokK, a B12-dependent radical SAM enzyme, revealing its mechanism for carbapenem antibiotic biosynthesis.
bioRxiv · Jul 10, 2021 · PreprintBiochemistry