Author

C. Townsend

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Assay:electrophysiology· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

A. Boal· 1 shared A. C. Tanjala· 1 shared A. Zingg· 1 shared B. Eicher· 1 shared C. A. Guzman· 1 shared C. Bear· 1 shared C. Esslinger· 1 shared C. Li· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperBiochemistry

A. Boal

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Comparison of a novel potentiator of CFTR channel activity to ivacaftor in ameliorating mucostasis caused by cigarette smoke in primary human bronchial airway epithelial cells

A. C. Tanjala, J. X. Jiang, P. D. W. Eckford, M. Ramjeesingh, C. Li, L. J. Huan, G. Langeveld, C. Townsend, D. Paone, J. Busch Petersen, R. Pekhletski, L. Tang, V. Raju, S. M. Rowe, C. Bear

This study compares a novel CFTR potentiator, SK-POT1, to ivacaftor in improving mucociliary clearance in airway epithelial cells exposed to cigarette smoke.

bioRxiv · Mar 1, 2024Physiology

Structural basis for carbapenam C-alkylation by TokK, a B12-dependent radical SAM enzyme

H. Knox, E. Sinner, C. Townsend, A. Boal, S. Booker

The paper presents x-ray crystal structures of TokK, a B12-dependent radical SAM enzyme, revealing its mechanism for carbapenem antibiotic biosynthesis.

bioRxiv · Jul 10, 2021 · PreprintBiochemistry

MTX-COVAB, a human-derived antibody with potent neutralizing activity against SARS-CoV-2 infection in vitro and in a hamster model of COVID-19

C. Esslinger, S. Schmitt, M. Weber, M. Hillenbrand, J. Seidenberg, A. Zingg, C. Townsend, B. Eicher, J. Rutkauskaite, P. Riese, C. A. Guzman, K. Fischer

The paper identifies a human-derived monoclonal antibody, MTX-COVAB, with potent neutralizing activity against SARS-CoV-2 in vitro and in a hamster model, showing efficacy against variants and readiness for clinical testing.

bioRxiv · Dec 1, 2020 · PreprintImmunology