Follicular helper- and peripheral helper-like T cells drive autoimmune disease in human immune system mice
M. Khosravi-Maharlooei, A. Vecchione, N. Danzl, H. W. Li, G. Nauman, R. Madley, E. Waffarn, R. Winchester, A. Ruiz, X. Ding, G. Fousteri, M. Sykes
The paper shows that PD-1+CD4+ Tfh-like and Tph-like cells in human immune system mice drive autoimmune disease, with disease progression linked to HLA-restricted T cell-APC interactions.
bioRxiv · May 2, 2024Immunology