Rapid hypermutation B cell trajectory recruits previously primed B cells upon third SARS-CoV-2 mRNA vaccination
L. Paschold, B. Klee, C. Gottschick, E. Willscher, S. Diexer, C. Schultheiss, D. Simnica, D. Sedding, M. Girndt, M. Gekle, R. Mikolajczyk, M. Binder
The paper tracks SARS-CoV-2 B cell hypermutation levels across vaccinations, showing increased somatic hypermutation after the third dose, which may explain better protection against variants like Omicron.
bioRxiv · Mar 1, 2022Immunology