Author

L. Paschold

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Assay:CITE-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

C. Schultheiss· 3 shared M. Binder· 3 shared D. Simnica· 2 shared A. Fasano· 1 shared A. Holtermann· 1 shared B. Klee· 1 shared C. Gottschick· 1 shared C. Santiskulvong· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersImmunology

C. Schultheiss

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Mutation-specific CAR T cells as precision therapy for IGLV3-21R110 expressing high-risk chronic lymphocytic leukemia

F. Maerkl, C. Schultheiss, M. Ali, S.-S. Chen, L. Egli, J. Mietz, O. Chijoke, L. Paschold, S. Spajic, A. Holtermann, J. Doerr, S. Stock, I. Piseddu, D. Anz, M. Duehren-von Minden, , M. Binder

This study develops CAR T cells targeting a specific mutation in CLL to selectively kill cancer cells while sparing healthy B cells.

bioRxiv · Sep 29, 2023 · PreprintCancer Biology

Rapid hypermutation B cell trajectory recruits previously primed B cells upon third SARS-CoV-2 mRNA vaccination

L. Paschold, B. Klee, C. Gottschick, E. Willscher, S. Diexer, C. Schultheiss, D. Simnica, D. Sedding, M. Girndt, M. Gekle, R. Mikolajczyk, M. Binder

The paper tracks SARS-CoV-2 B cell hypermutation levels across vaccinations, showing increased somatic hypermutation after the third dose, which may explain better protection against variants like Omicron.

bioRxiv · Mar 1, 2022Immunology

Identification of a unique TCR repertoire, consistent with a superantigen selection process in Children with Multi-system Inflammatory Syndrome

R. A. Porritt, L. Paschold, M. Noval Rivas, M. H. Cheng, L. M. Yonker, H. Chandnani, M. Lopez, D. Simnica, C. Schultheiss, C. Santiskulvong, J. Van Eyk, A. Fasano, I. Bahar, M. Binder, M. Arditi

This study identifies a skewed TCR repertoire in MIS-C patients, with TRBV11-2 expansion linked to disease severity and superantigen-like interactions with SARS-CoV-2 spike protein.

bioRxiv · Nov 9, 2020 · PreprintImmunology