Dysregulated nuclear export of the late herpes simplex virus 1 transcriptome through the vhs-VP22 axis uncouples virus cytopathic effect and virus production
K. Pheasant, D. Perry, E. Wise, V. Cheng, G. Elliott
This paper shows that HSV1 lacking VP22 replicates efficiently without causing cytopathic effect, but spontaneously mutates to restore late protein synthesis and CPE through vhs mutations.
bioRxiv · Nov 2, 2022 · PreprintMicrobiology