K. Pheasant

Dysregulated nuclear export of the late herpes simplex virus 1 transcriptome through the vhs-VP22 axis uncouples virus cytopathic effect and virus production

This paper shows that HSV1 lacking VP22 replicates efficiently without causing cytopathic effect, but spontaneously mutates to restore late protein synthesis and CPE through vhs mutations.

Nuclear-cytoplasmic compartmentalization of the herpes simplex virus 1 infected cell transcriptome is co-ordinated by the viral endoribonuclease vhs and cofactors to facilitate the translation of late proteins

This study reveals that HSV1's vhs endoribonuclease, along with cofactors VP22 and VP16, coordinates nuclear-cytoplasmic compartmentalization of the infected cell transcriptome to regulate late protein translation.