Author

E. Zumbro

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:simulation· 2 Approach:statistical model· 2 Approach:deep learning· 1

Frequent Co-Authors

A. Alexander-Katz· 3 shared J. Witten· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

2 top collaborators · 1 mutual co-author link

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3 shared papersBiophysics

A. Alexander-Katz

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3 papers

Recent·Most cited

Multivalent polymers can control phase boundary, dynamics, and organization of liquid-liquid phase separation

E. Zumbro, A. Alexander-Katz

This study uses simulations to show how multivalent polymer structure affects liquid-liquid phase separation dynamics and organization in biological systems.

bioRxiv · Dec 31, 2020 · PreprintBiophysics

Polymer Stiffness Regulates Multivalent Binding and Liquid-Liquid Phase Separation

E. Zumbro, A. Alexander-Katz

This paper shows that flexible polymers bind more strongly to targets and nucleate phase separation at lower energy than rigid polymers, with implications for pathogen inhibition and neurodegenerative diseases.

bioRxiv · May 13, 2020Biophysics

Computational Insights Into Avidity of Polymeric Multivalent Binders

E. Zumbro, J. Witten, A. Alexander-Katz

This study uses Brownian dynamics simulations to show that longer multivalent polymers increase binding avidity to targets but reach a limit at high degrees of polymerization, and improve binding efficiency through inter-target interactions.

bioRxiv · Feb 8, 2019Bioengineering