Oxaliplatin and 5-Fluorouracil induce p53-p21-pRb-associated cell cycle arrest and a transient senescence-like phenotype in patient-derived low-grade serous ovarian cancer cells
Rewati Prakash, Benjamin N. Forgie, Alicia Alejandra Goyeneche, Edith Zorychta, Abu Noman, Lucy Gilbert, Carlos Marcelo Telleria
This study shows that oxaliplatin and 5-fluorouracil induce a transient senescence-like phenotype and G0/G1-phase arrest in LGSOC cells via the p53-p21-pRb pathway, without killing the cells.
bioRxiv · Sep 23, 2026 · PreprintCancer Biology