Spatial and molecular insights into microglial roles in cerebellar aging
Andy Po‐Yi Tsai, Douglas E. Henze, Eduardo Ramirez Lopez, James Haberberger, Chuanpeng Dong, Nannan Lu, Micaiah Atkins, Emma K. Costa, Amelia Farinas, Hamilton Se‐Hwee Oh, Patricia Morán Losada, Yann Le Guen, Alina Isakova, Stephen R. Quake, Tony Wyss‐Coray
The paper investigates age-related changes in cerebellar microglia using single-nuclei RNA sequencing and MERFISH, finding enhanced neuroprotective immune activation and proximity to granule cells in aged mice.
Cell Reports · Nov 26, 2025Peer-reviewedNeuroscience