The Main protease (Mpro) from SARS-CoV-2 triggers plasma clotting in vitro by activating coagulation factors VII and FXII
Anna Pagotto, Federico Uliana, Elena Cavedon, Giulia Nordio, Andrea Pierangelini, Laura Acquasaliente, Maria Ludovica Macchia, Massimo Bellanda, Barbara Gatto, Giustina De Silvestro, Piero Marson, Darío Gregori, Paolo Simioni, Paola Picotti, Vincenzo De Filippis
This study shows that SARS-CoV-2 main protease (Mpro) activates coagulation factors VII and XII, increasing plasma clotting probability by 2.5-fold.
Communications Biology · Aug 1, 2025Peer-reviewedBiochemistry