Liver Fatty Acid Binding Protein (FABP1) Affects Cytochrome P450 2C9 (CYP2C9)-Mediated Metabolism in Human Liver Models
Yue Winnie Wen, Eli Friedman, Alex Zelter, King Clyde B. Yabut, Abhinav Nath, Michael J. MacCoss, Nina Isoherranen
The paper shows that FABP1 affects CYP2C9-mediated drug metabolism in human liver models, improving prediction accuracy when included in physiologically based models.
bioRxiv · Oct 19, 2026 · PreprintPharmacology & Toxicology