Abhinav Nath

The paper shows that FABP1 affects CYP2C9-mediated drug metabolism in human liver models, improving prediction accuracy when included in physiologically based models.

This study shows HSPB1 and HSPB5 use distinct N-terminal regions to delay tau aggregation, with HSPB1 under normal conditions and HSPB5 under stress.

This study develops a plasma protein binding model to predict unbound cortisol and cortisone concentrations by accounting for changes in ligand and protein concentrations across physiological states.

This study uses pulsed HDX-MS to investigate whether tau4RD fibril polymorphism is imprinted during early aggregation or arises from structural rearrangements later in the process.

This study shows drugs form ternary complexes with human FABP1 and that FABP1 binding alters drug metabolism by affecting CYP2C9 activity.

The paper identifies tryptanthrin analogs as potent substoichiometric inhibitors of tau4RD aggregation, showing low nanomolar potency and demonstrating structure-activity relationship principles for tau targeting.