Molecular and cellular processes disrupted in the early postnatal Down syndrome prefrontal cortex
Ryan D. Risgaard, Kalpana Hanthanan Arachchilage, Sara Knaack, Masoumeh Hosseini, Rachel J Chen, Pubudu Kumarage, Danielle K. Schmidt, Xiang Huang, Jie Sheng, Carlos J. Wang, Elisa Giusti, Shuang Liu, Su-Chun Zhang, Daifeng Wang, Anita Bhattacharyya, André M. M. Sousa
This study uses single-nucleus multiomic sequencing to analyze gene expression and chromatin accessibility in the Down syndrome prefrontal cortex, revealing widespread dysregulation in metabolic, synaptic, and neuroinflammatory pathways.
Science · Apr 23, 2026Peer-reviewedNeuroscience