NeuroscienceSciencePeer-reviewed
Molecular and cellular processes disrupted in the early postnatal Down syndrome prefrontal cortex
Ryan D. Risgaard, Kalpana Hanthanan Arachchilage, Sara Knaack…·André M. M. Sousa
This study uses single-nucleus multiomic sequencing to analyze gene expression and chromatin accessibility in the Down syndrome prefrontal cortex, revealing widespread dysregulation in metabolic, synaptic, and neuroinflammatory pathways.