Author

Ella Bedford

The University of Texas MD Anderson Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Han XuiD· 3 shared Rongjie Fu· 3 shared Wei HeiD· 3 shared Liang ZhangiD· 2 shared Mark T. BedfordiD· 2 shared Oscar David VillarrealiD· 2 shared Taiping CheniD· 2 shared Yalong WangiD· 2 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersCancer Biology

Han XuORCID

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3 papers

Recent·Most cited

Acquired resistance to the PRMT5 inhibitor confers collateral sensitivity to MEK inhibition in MTAP-null non-small cell lung cancer

Rongjie Fu, Yalong Wang, Ishita Rehman, Ella Bedford, Sana Sharif, Nghi D. Nguyen, Reid Trenton Powell, Andrew Adams, W LIU, Shuyue Wang, Wei He, Yue Lu, Bin Liu, Pooja Anil Shah, Jordi Ahnert Rodon, , Han Xu

The paper identifies collateral sensitivity to MEK inhibition in MTAP-null NSCLC cells that develop resistance to PRMT5 inhibitors.

Biomolecules · Aug 17, 2026Peer-reviewedCancer Biology

Systematic decomposition of sequence determinants governing CRISPR/Cas9 specificity

Rongjie Fu, Wei He, Jinzhuang Dou, Oscar David Villarreal, Ella Bedford, Helen H. Wang, Connie Hou, Liang Zhang, Yalong Wang, Dacheng Ma, Yiwen Chen, Xue Gao, Martin Depken, Han Xu

This study systematically identifies sequence determinants of CRISPR/Cas9 specificity by analyzing off-target effects of 1,902 gRNAs on 13,314 targets, revealing three key factors and developing a predictive tool.

Nature Communications · Jan 25, 2022Peer-reviewedSystems Biology

De novo Identification of Essential Protein Domains from CRISPR/Cas9 Tiling-sgRNA Knockout Screens

Wei He, Liang Zhang, Oscar David Villarreal, Rongjie Fu, Ella Bedford, Jingzhuang Dou, Anish Y. Patel, Mark T. Bedford, Xiaobing Shi, Taiping Chen, Blaine Bartholomew, Han Xu

The paper introduces ProTiler, a method to identify essential protein domains from CRISPR/Cas9 tiling-sgRNA screens, finding 175 CKHS regions with high overlap to annotated domains and novel unannotated domains.

Nature Communications · Oct 4, 2019Peer-reviewedBioinformatics