Author

Liang Zhang

The University of Texas MD Anderson Cancer CenterORCID 0000-0002-8579-4385Unclaimed ORCID profile · follow to get notified of new preprints

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Liang Zhang6 papers · China West Normal University

Biology Disciplines

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Systems Biology· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 3 Research Focus:benchmarking· 2 Approach:statistical model· 2 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:machine learning (classical)· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Han XuiD· 3 shared Rongjie Fu· 3 shared Wei HeiD· 3 shared Ella Bedford· 2 shared Oscar David VillarrealiD· 2 shared Yiwen CheniD· 2 shared Anish Y. PateliD· 1 shared Blaine BartholomewiD· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersSystems Biology

Han XuORCID

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3 papers

Recent·Most cited

Systems BiologyNucleic Acids ResearchPeer-reviewedAug 14, 2023

Guide-specific loss of efficiency and off-target reduction with Cas9 variants

Liang Zhang, Wei He, Rongjie Fu…·Han Xu

The paper evaluates efficiency and off-target effects of high-fidelity Cas9 variants with different sgRNAs and develops a computational framework to predict their performance.

22 citations

CRISPR screenmachine learning (classical)

𝕏 PostBluesky

Systems BiologyNature CommunicationsPeer-reviewedJan 25, 2022

Systematic decomposition of sequence determinants governing CRISPR/Cas9 specificity

Rongjie Fu, Wei He, Jinzhuang Dou…·Han Xu

This study systematically identifies sequence determinants of CRISPR/Cas9 specificity by analyzing off-target effects of 1,902 gRNAs on 13,314 targets, revealing three key factors and developing a predictive tool.

55 citationstop 5%

CRISPR screenstatistical model

𝕏 PostBluesky

BioinformaticsNature CommunicationsPeer-reviewedOct 4, 2019

De novo Identification of Essential Protein Domains from CRISPR/Cas9 Tiling-sgRNA Knockout Screens

Wei He, Liang Zhang, Oscar David Villarreal…·Han Xu

The paper introduces ProTiler, a method to identify essential protein domains from CRISPR/Cas9 tiling-sgRNA screens, finding 175 CKHS regions with high overlap to annotated domains and novel unannotated domains.

69 citations

CRISPR screenstatistical model

𝕏 PostBluesky