Microtubule curling as an efficient readout to uncover fundamental concepts of axonal cell biology and neurodegeneration
André Voelzmann, Milli Owens, Robin Beaven, William Cairns, Abigail Elliot, Sheng-Hui Feng, Judith B. Fülle, Catarina Gonçalves‐Pimentel, Ines Hahn, Ella Jones, Kodie Norris, Yu-Ting Liew, Lydia Lorenzo-Cisneros, Lucy O'Donoghue, Liliana M. Pinho-Correia, , Andreas Prokop
The paper identifies microtubule-curling as a marker of axonal atrophy by analyzing gene deficiencies in Drosophila neurons, revealing two distinct mechanisms linked to neurodegeneration.
bioRxiv · Jun 27, 2025 · PreprintCell Biology