Accelerating drug development in infectious diseases using zebrafish disease models supported by pharmacokinetic pharmacodynamic modeling as new approach methodology (NAM)
Gabriel Forn‐Cuní, Bart van Lieshout, Bjørn E. V. Koch, Cristina Villellas, Stijn Van Asten, Dina Berlina, Ellen Lanckacker, Bart Stoops, Rob J. Vreeken, Dirk Roymans, Elke H. J. Krekels, J. G. Coen van Hasselt, Herman P. Spaink, Rob Christiaan van Wijk
Zebrafish larva infection experiments plus pharmacokinetic-pharmacodynamic (PKPD) modelling gave bedaquiline's in vivo Emax and EC50 against M. marinum in about 2 months; waterborne clarithromycin barely entered larvae.
bioRxiv · Oct 30, 2026 · PreprintPharmacology & Toxicology✦ In-depth digest