Fast and Ultra-Capable Protein Design: Advancing the Frontier Through Atomistic SE(3)-Equivariance with Genie 3
Yi‐Cheng Lin, Minji Lee, Aakarsh Vermani, Ellena Jiang, Sebastiaan De Cooman, Matěj Špeťko, Mohammed AlQuraishi
This paper introduces Genie 3, a diffusion model that improves protein design by combining SE(3)-equivariance with hallucination, achieving state-of-the-art results in binder design and motif scaffolding.
bioRxiv · May 5, 2026 · PreprintBioinformatics