CA19-9 induces microenvironment remodeling in pancreatic ductal adenocarcinoma
Jasper Hsu, Hyemin Song, Satoshi Ogawa, Casie S. Kubota, Kristina L. Peck, Emily Jacobs, Lizmarie Garcia-Rivera, Jonathan Zhu, Yuan Sui, Woncheol Jung, Yang Dai, Jan C. Lumibao, Chelsea R. Bottomley, Kassidy Curtis, Mars Bau, , Dannielle D. Engle
This study identifies CA19-9's role in remodeling the PDAC tumor microenvironment by inducing IL1a and TGFb, leading to immunosuppressive changes that can be mitigated by blocking these factors.
bioRxiv · May 26, 2026 · PreprintCancer Biology