Dual GLP-1/FGF21 agonism suppresses voluntary alcohol consumption, alcohol choice, and nucleus accumbens dopamine modulation
Bart J. Cooley, Parul Sirohi, Caslin A. Gilroy, Joy (Shijia) Tong, Catherine G. Price, Emily Mitchell, Willow Heler, Ashutosh Chilkoti, Andrew John Lawrence, Gavan P. McNally, E. Zayra Millan
This study shows that a dual GLP-1/FGF21 agonist reduces alcohol consumption and dopamine responses in mice by altering decision-making processes.
bioRxiv · May 10, 2026 · PreprintAnimal Behavior & Cognition