High-throughput Eukaryotic Screening of Putative Anti-CRISPR Proteins against SpyCas9 and SauCas9
Dinie Zheng, Tristan R Grieve, Emma Fidacaro, Michael James Chambers, Meru J. Sadhu
The paper screens hundreds of anti-CRISPR homologs to inhibit SpyCas9 and SauCas9, revealing evolutionary patterns and discovering three novel Acr families.
bioRxiv · Oct 21, 2026 · PreprintGenetics