Michael James Chambers

The paper screens hundreds of anti-CRISPR homologs to inhibit SpyCas9 and SauCas9, revealing evolutionary patterns and discovering three novel Acr families.

This study screens genetic variants of PKR to identify those that resist diverse viral pseudosubstrate inhibitors, finding shared resistance mechanisms across different inhibitors.

The paper systematically assesses the functional impact of CPOX variants under different environmental conditions, revealing mercury-dependent variant effects and improving variant classification.

This study identifies K3-resistant variants in the PKR kinase domain and shows their enrichment under positive selection and resilience to viral adaptation.

The paper systematically explores genetic variants in human PKR and vaccinia virus K3 to understand their evolutionary dynamics and functional interactions.

The paper uses long-read sequencing to identify pangenomic genes contributing to yeast phenotypic variation by resolving QTLs that are missed by short-read methods.